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M94A0337.TXT
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1994-10-08
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Document 0337
DOCN M94A0337
TI Viruses and Langerhans cell histiocytosis: is there a link?
DT 9412
AU McClain K; Weiss RA; Baylor College of Medicine, Texas Children's
Hospital, Houston; 77030.
SO Br J Cancer Suppl. 1994 Sep;23:S34-6. Unique Identifier : AIDSLINE
MED/94355211
AB As a rare, sporadic disease Langerhans cell histiocytosis (LCH) presents
a difficult problem in defining a likely etiology. Epidemiological data
would not a priori lead one to choose a viral etiology. However, there
are rare tumours which occur as sequelae of common infections from
Epstein-Barr virus or human papilloma viruses. Likewise some viruses can
cause cells to elaborate cytokines which could ultimately stimulate
Langerhans cell growth. There is only a small amount of experimental
data testing the hypothesis that viruses might be associated with LCH.
The theoretical constructs surrounding this question and new data
refuting the association are summarised.
DE Adenoviridae/ISOLATION & PURIF Cytomegalovirus/ISOLATION & PURIF DNA,
Viral/*ISOLATION & PURIF Herpesvirus 4, Human/ISOLATION & PURIF
Histiocytosis, Langerhans-Cell/METABOLISM/*MICROBIOLOGY Human
HIV/ISOLATION & PURIF HTLV-BLV Viruses/ISOLATION & PURIF In Situ
Hybridization Parvovirus/ISOLATION & PURIF Simplexvirus/ISOLATION &
PURIF Support, Non-U.S. Gov't JOURNAL ARTICLE REVIEW REVIEW
LITERATURE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).